KO LAP-YAN (Alex Fong) pulls himself together following his wife’s death, and changes his job, becoming a Consultant of Forensic Psychiatry Department. As soon as he assumes his office, he cooperates with another Consultant, Dr. CHEUK WAI-KIU (YoYo Mung), conducting clinical evaluations and treatments on a mentally ill patient. During the examination, a felony involving an evil cult is unveiled, so LAP-YAN joins forces with LAM CHUNG-YAN (Tavia Yeung), an Inspector of Regional Crime Unit, to probe into the matter. Gradually, a subtle bond between Department of Forensic Psychiatry and the Regional Crime Unit becomes established. Each time she encounters a convoluted case, CHUNG-YAN goes to seek aid from LAP-YAN, whereas WAI-KIU seeks advice from LAP-YAN whenever she has relationship problems. Furthermore, with the spiritual support from his good colleagues as well as good friends, LIN CHI-SUM (Ram Chiang) and LEUNG KAI-WING (Edwin Siu), LAP-YAN actively turns over a new leaf. Out of the blue, while a horrific serial murder case stirs up some turbulence, LAP-YAN discovers that there is an utmost connection between the case and CHUNG-YAN.

高立仁 (方中信) 丧妻后重拾斗志，转职成为法医精神科的顾问医生，甫入职便与另一顾问医生卓慧翘 (蒙嘉慧) 合作，为一名精神病患者提供临床评估及治疗，过程中揭发一宗涉及邪教的严重罪行，因而与重案组探员林颂恩 (杨怡) 联手调查，法医精神科渐与重案组建立微妙的合作关系，颂恩每遇棘手案件会找立仁帮忙，而慧翘每遇感情烦恼亦会找立仁解困，加上两位好同事兼好友连志森 (蒋志光) 和梁启荣 (萧正楠) 的精神支柱，令立仁积极重建新生活，谁料一宗恐怖连环凶杀案牵起波澜，立仁竟发现案件与颂恩有莫大关联……